Tampa, Florida – A recent study published in JAMA Network Open suggests that changing the order of treatment for breast cancer patients could significantly improve their quality of life. Dr. Roberto Diaz, a Radiation Oncologist from the Moffitt Cancer Center, highlighted the potential shift in treatment paradigms if the study’s results are confirmed in larger studies. Breast cancer patients often undergo post-mastectomy radiation after surgery, which can lead to delayed reconstruction and potentially poor cosmetic outcomes due to radiation effects.
Traditionally, patients must wait six to 12 months after radiation before undergoing cosmetic reconstruction to reduce the risk of deformities. This delay in reconstruction can result in multiple surgeries and challenges for patients seeking post-mastectomy radiation. Dr. Ronica Nanda from the Moffitt Cancer Center emphasized the impact of these challenges on patients’ quality of life and cosmetic outcomes.
A phase two clinical trial conducted by Dr. Mark V. Schaverien at the University of Texas MD Anderson Cancer Center explored the effects of administering radiation before surgery in 48 breast cancer patients. This new approach, known as pre-mastectomy radiotherapy, allowed patients to receive reconstruction surgery immediately after completing radiation without compromising outcomes. The study found the revised treatment sequence to be feasible without resulting in complications.
Experts, including Dr. Clary Evans from Northwell Health, expressed optimism about the potential benefits of this new treatment approach. The revised sequence could offer improved cosmetic outcomes, reduce the need for multiple surgical procedures, and shorten treatment times for some patients. Despite these promising findings, experts caution that more research is needed to fully understand the implications of changing the treatment order for breast cancer patients.
Looking ahead, a larger clinical trial involving 126 patients commenced in April 2023 to further validate the initial study’s findings. Dr. Diaz eagerly anticipates the results of the upcoming Phase 3 study for more insights into the long-term outcomes of this innovative treatment approach. Breast cancer treatment is complex and personalized, and advancements in treatment strategies could offer promising improvements in patient outcomes and quality of life.