Baltimore, Maryland: A recent study conducted by researchers from Johns Hopkins Medicine and the National Institute on Aging sheds light on the benefits of intermittent fasting and a healthy diet for brain health improvement in older adults with obesity and insulin resistance. The study, published in Cell Metabolism, involved 40 participants who were randomly assigned to either an intermittent fasting regimen or a standard healthy diet recommended by the US Department of Agriculture.
Insulin resistance is a common issue among individuals with obesity and is often associated with an increased risk of Alzheimer’s disease and cognitive impairments. Therefore, finding effective strategies to improve metabolic health and brain function in such individuals is crucial.
The study results showed that both dietary approaches led to improvements in cognitive function and insulin resistance, with intermittent fasting showing more significant enhancements in memory and executive function compared to the healthy diet. This suggests that both intermittent fasting and a healthy diet can have positive effects on brain health for individuals with obesity and insulin resistance.
Through analyzing extracellular vesicles shed from neurons, the researchers were able to assess the impact of the two diets on brain function biomarkers. This method provided valuable insights into how dietary interventions can influence brain health and cognitive function in at-risk individuals.
It is important to note that while both diets showed positive outcomes, some participants in the study reported minor side effects such as constipation, loose stools, and occasional headaches. Additionally, increased levels of a neurofilament protein were observed in both diet groups, raising questions about their implications for brain health and neuroplasticity in neurons.
As researchers continue to explore the link between diet and brain health, it is essential for individuals interested in intermittent fasting to consult with healthcare providers to ensure it is safe for them, especially those with certain medical conditions like type 1 diabetes or eating disorders.
The findings of this study contribute to the growing body of research on the impact of dietary interventions on brain health and metabolic function in individuals with obesity and metabolic disorders. Further studies are needed to explore the long-term effects of intermittent fasting and healthy diets on cognitive function and overall well-being in at-risk populations.